Uni Münster Med. Fakultaet
IoB
NEWS
2024-10-01
Congratulations to Felix Manske for the succesful defense of the PhD thesis.
2024-06-13
"Application of a new data management system to the study of the gut microbiome of children who are small for their gestational age" by Manske et al. has been uploaded to bioRxiv.
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2024-06-07
"Interplay of miR-542, miR-126, miR-143 and miR-26b with PI3K-Akt is a Diagnostic Signal and Putative Regulatory Target in HPV-Positive Cervical Cancer" by Akram Rahimi-Moghaddam, Nassim Ghorbanmehr, Sedigheh Gharbi, Fatemeh Nili and Eberhard Korsching has been published by Biochemical Genetics
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2024-02
NewickTreeModifier: a simple web page to prune and modify Newick trees
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2023-08-28
"The complete sequence of a human Y chromosomeā€¯ by T2T Consortium has been published by Nature
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2022-10-28
"The new uORFdb: integrating literature, sequence, and variation data in a central hub for uORF research" by Felix Manske, Lynn Ogoniak, Norbert Grundmann and Wojciech Makalowski has been published by Nucleic Acids Research.
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2022-07-08
"A Map of 3' DNA Transduction Variants Mediated by Non-LTR Retroelements on 3202 Human Genomes" by Reza Halabian and Wojciech Makalowski has been published by Biology.
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2022-06
"paPAML: An Improved Computational Tool to Explore Selection Pressure on Protein-Coding Sequences" by Lynn Ogoniak, Norbert Grundmann and others
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2022-05-14
"Mobilome of Apicomplexa Parasites" by Rodriguez and Makalowski has been published by Genes.
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2022-04-27
"Software evaluation for de novo detection of transposons" by Rodriguez and Makalowski has been published by Mobile DNA.
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2022-04-01
"From telomere to telomere: The transcriptional and epigenetic state of human repeat elements" by T2T consortium has been published by Science.
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2022-02-12
"Global research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing" by GRAID consortium that IoB is part of has been published by BMC Research Notes.
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Origin and evolution of U-12 dependent introns

Pre-mRNA splicing in eukaryotes is a fundamental step in gene expression and represents an important level at which the expression of protein-coding genes can be regulated . In higher eukaryotes, there are two classes of nuclear pre-mRNA introns. The most abundant class consists of U2-dependent introns (U2 introns), whereas the second rarer class (<0.4% of introns) consists of U12-dependent introns (U12 introns). U12 introns have been found in the nuclear genomes of vertebrates, plants, and insects. Introns belonging to these two distinct classes are spliced by two different spliceosomes: the major U2-type spliceosome and the less abundant U12-type spliceosome. Although the first U12 introns to be described had AT-AC terminal dinucleotides, the majority of U12-type introns contain GT-AG, and a small number contain other noncanonical terminal dinucleotides. We use statistical methods to discriminate the two classes of introns and investigate U12-introns evolutionaty distribution.

2018-11-15 11:50