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2019-11-04
Congratulations Matias for the "Best Poster" award at the X International Conference on Bioinformatics - Celebrating the 10th Anniversary of SoIBio and 10th Anniversary of the Master in Bioinformatics Uruguay.
2019-10-03
"Statins: Complex outcomes but increasingly helpful treatment options for patients" by Mohammadkhani, Korsching et al. has been published by European Journal of Pharmacology.
Goto
2019-10-01
Congratulations to Marten - another successful Master of Science.
2019-09-16
"An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo" by Israel, Makalowski et al. has been published by Scientific Reports.
Goto
2019-08-05
"Bioinformatics of nanopore sequencing" by Makalowski and Shabardina has been published by Journal of Human Genetics
Goto
2019-07-23
Researchers in the field of bioinformatics at Muenster University, Germany and Mr. Fujihiko Minamoto (second from left)
Goto
2019-06-18
Felix defended his master
2019-05-29
Wolfgang takes his retirement
2019-05-29
Jonas made his defense
2019-01-24
"NanoPipe - a web server for nanopore MinION sequencing data analysis" by Shabardina et al. has been published by GigaScience.
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Anna Neumann

Anna N

Cancer is one of the most common causes of death world wide and in most cancer patients metastasis is the main cause of death. Osteosarcoma (OS) is the most common primary malignancy of bone, with up to 80% of patients suffering from metastasis or micrometastatic disease at the time of diagnosis. For the metastatic potential of tumours invasiveness plays an important role. The focus of this study is to determine new candidate genes for invasiveness. For that OS cell lines are analysed using a modified Boyden Chamber assay to separate invasive and non-invasive cells. After that total RNA of both fractions is analysed by Illumina hybridisation Arrays (V3 bead arrays). Pair wise comparison (using an S-Plus based evaluation pipeline) yield stable differently expressed genes between invasive and non-invasive cells. These genes are involved in pathways such as cell motility, cell communication or signal transduction. Therefore these candidate genes a) support the established experimental model for metastasis of OS cells and b) give strong clues for a core pattern of metastasis related genes. For functional characterization a combination of knock-down experiments (RNAi) and invasion assay is used. To validate the results RT-PCR and immunohistochemistry on a larger sample using OS-TMAs is processed. Determined genes and pathways are correlated with clinical parameters like metastasis, survival and chemotherapy sensitivity in order to improve the understanding of the biology of OS.

2011-06-28 15:20