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NEWS
2019-11-04
Congratulations Matias for the "Best Poster" award at the X International Conference on Bioinformatics - Celebrating the 10th Anniversary of SoIBio and 10th Anniversary of the Master in Bioinformatics Uruguay.
2019-10-03
"Statins: Complex outcomes but increasingly helpful treatment options for patients" by Mohammadkhani, Korsching et al. has been published by European Journal of Pharmacology.
Goto
2019-10-01
Congratulations to Marten - another successful Master of Science.
2019-09-16
"An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo" by Israel, Makalowski et al. has been published by Scientific Reports.
Goto
2019-08-05
"Bioinformatics of nanopore sequencing" by Makalowski and Shabardina has been published by Journal of Human Genetics
Goto
2019-07-23
Researchers in the field of bioinformatics at Muenster University, Germany and Mr. Fujihiko Minamoto (second from left)
Goto
2019-06-18
Felix defended his master
2019-05-29
Wolfgang takes his retirement
2019-05-29
Jonas made his defense
2019-01-24
"NanoPipe - a web server for nanopore MinION sequencing data analysis" by Shabardina et al. has been published by GigaScience.
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Origin and evolution of U-12 dependent introns

Pre-mRNA splicing in eukaryotes is a fundamental step in gene expression and represents an important level at which the expression of protein-coding genes can be regulated . In higher eukaryotes, there are two classes of nuclear pre-mRNA introns. The most abundant class consists of U2-dependent introns (U2 introns), whereas the second rarer class (<0.4% of introns) consists of U12-dependent introns (U12 introns). U12 introns have been found in the nuclear genomes of vertebrates, plants, and insects. Introns belonging to these two distinct classes are spliced by two different spliceosomes: the major U2-type spliceosome and the less abundant U12-type spliceosome. Although the first U12 introns to be described had AT-AC terminal dinucleotides, the majority of U12-type introns contain GT-AG, and a small number contain other noncanonical terminal dinucleotides. We use statistical methods to discriminate the two classes of introns and investigate U12-introns evolutionaty distribution.

2018-11-15 11:50