WWU Münster UKM
IoB
NEWS
2022-06
"paPAML: An Improved Computational Tool to Explore Selection Pressure on Protein-Coding Sequences" by Lynn Ogoniak, Norbert Grundmann and others
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2022-05-14
"Mobilome of Apicomplexa Parasites" by Rodriguez and Makalowski has been published by Genes.
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2022-04-27
"Software evaluation for de novo detection of transposons" by Rodriguez and Makalowski has been published by Mobile DNA.
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2022-04-01
"From telomere to telomere: The transcriptional and epigenetic state of human repeat elements” by T2T consortium has been published by Science.
Goto
2022-02-12
"Global research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing” by GRAID consortium that IoB is part of has been published by BMC Research Notes.
Goto
2021-08-05
Congratulations to Reza and Matias on the excellent contribution on TE-driven DNA transductions in the human genome
Goto
2021-05-29
"Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer" was published by MDPI
Goto

Amit Pande

Amit P

My work mainly focuses on the biology of transposable elements with an emphasis on the role of Alu elements in alternative splicing and gene regulation.

Alu elements are the most abundant repetitive elements in the human genome; they emerged 65 million years ago from a fusion of the 7SL RNA-originated monomers and amplified throughout the human genome by retrotransposition to reach the present number of more than one million copies. Over the last years, several lines of evidence demonstrated that these elements modulate gene expression at the post-transcriptional level in at least three independent manners. They have been shown to be involved in alternative splicing, RNA editing and translation regulation.

Delineating the role of Alu elements, participating as basal/core and proximal promoters , in Primates, is currently the focus of my work here since July 2008. The evolutionary context in which these non-autonomous elements give rise to the formation of "new genes" in Primates enthralls me further.

2010-10-18 14:19